"Poop Today?" was the first video I watched on youtube. We got a new computer in 2006 and the first thing I googled was "poop", and this came up.
Fett's Vette is another early youtube video I remember watching with my friend Zane. We would re-enact the video with his Star Wars action figures.
End of Ze World is a video I saw before youtube even existed. My cousin had this video burned to a CD and brought it to my house to show me.I believe it was originally uploaded to newgrounds, but I remember it on jeffiscool.com
This video from the Onion might be some of the best sketch writing ever. It cracks me up every time I watch it.